Neiropum is a probiotic supplement designed to support the body's health by strengthening the immune and digestive systems, reducing anxiety and improving mental health. The drug also promotes the production of important neurotransmitters of the nervous system, such as GABA (gamma-aminobutyric acid), dopamine and serotonin.

The main advantages of the drug:

Supports the nervous system: promotes the production of neurotransmitters (GABA, dopamine, serotonin), which affect mood and psycho-emotional state.
Reduced anxiety and improved mood due to the antidepressant and analgesic properties of GABA produced by probiotic bacteria.
Support for the digestive system: a complex of live bacteria helps maintain the balance of microflora and prevents the development of pathogenic flora.
Strengthening the immune system through a stimulating effect on the immune system.

Features for children with autism: Probiotics in Neiropum do not irritate the immune system in children with autism spectrum disorders (ASD), as lyophilized bacteria are immobilized on cellulose. This form of delivery ensures gentle interaction with the body, minimizing the risk of negative reactions and increasing the tolerability of the drug in children with autism. Maintaining healthy microflora and normalizing intestinal functions have a positive effect on the psychoemotional state and reduce anxiety, which is especially important for children with ASD.

Children with autism spectrum disorders (ASD) are four times more likely to have gastrointestinal (GI) symptoms than children without the disorder. These symptoms include constipation, diarrhea, bloating, pain, reflux, vomiting, gas, foul-smelling stools, and food allergies.
The psychobiotics in Neiropum belong to a class of probiotics that regulate the activation of the vagus nerve through neurotransmitters such as GABA, serotonin, glutamate, and proteins such as brain-derived neurotrophic factors. These substances play a key role in regulating the balance of neuronal excitation and inhibition, influencing mood, anxiety, cognitive function, learning and memory, and appetite.
The specially selected formula of psychobiotic strains in Neiropum modulates the release of GABA, serotonin and acetylcholine from enterochromaffin cells in the intestine, which helps improve mood and reduce anxiety.

Research:

Impact on children with ASD:

Children with ASD often experience gastrointestinal (GI) issues that can exacerbate behavioral problems. Probiotic strains such as Bifidobacterium and Lactobacillus have been shown to improve GI health and reduce inflammation by modulating cytokines and increasing anti-inflammatory markers such as IL-10.

This modulation helps alleviate GI symptoms associated with ASD and may contribute to improved behavior and reduced anxiety. Having a balanced gut microbiota is critical because disturbances are associated with neurobehavioral symptoms and immune responses associated with ASD.

Probiotics have the potential to restore gut balance and reduce neuroinflammation, improving cognitive and social function in children with ASD.

Potential effects on children with ADHD:

Neiropum, a product containing freeze-dried live bacteria in this combination, may have a positive effect on children with attention deficit hyperactivity disorder (ADHD) due to the effect of probiotics on the gut microbiota and through it on the brain and behavior. This mechanism is known as the “gut-brain axis ,” and research suggests that the health of the microbiota may be linked to cognitive function and emotional regulation.

Improved mood and reduced irritability :

Lactobacillus rhamnosus and L. reuteri are associated with the production of serotonin, which helps stabilize mood.

Bifidobacterium longum may help lower cortisol levels, reducing stress and anxiety.

Stimulation of cognitive function :

Bacillus coagulans and L. plantarum affect the improvement of attention and memory, which is important for children with ADHD.

Streptococcus salivarius may be involved in the synthesis of metabolites that improve neurotransmitter activity.

Reducing hyperactivity :

Probiotics such as Bifidobacterium adolescentis and Lactobacillus fermentum may help regulate inflammation, which has been linked to reduced hyperactivity.

General improvement in behavior :

Bacillus megaterium may promote microflora balance and reduce behavioral symptoms by maintaining healthy microbiota levels.

Antioxidant and anti-inflammatory action :

The use of excipients such as silicon dioxide in combination with probiotics helps reduce oxidative stress, which is often seen in children with ADHD.

Additional benefits:

Immobilization on cellulose : this technology makes the product more tolerable, especially for children with allergies or gastrointestinal problems.

Immune support : Strengthening the immune system through normalization of microbiota, which can reduce the risk of secondary diseases that worsen the child's condition.

The drug can be used as part of a comprehensive therapy, including dietary nutrition, psychological support and other medications. It will be especially effective in children who have already been diagnosed with microbiota problems, which is common in ADHD.

How and in what cases Neiropum can be effective

Functional disorders of the nervous system and increased anxiety

Through the gut-brain axis, probiotics can influence the production of neurotransmitters (serotonin, GABA) and the level of inflammatory cytokines, which in turn affects mood and feelings of stress.
Neuropeptides in the composition of “Neiropum” additionally “target” the action on the cells of the nervous system, supporting its stable functioning.

Irritable bowel syndrome (IBS), dysbiosis

If gastrointestinal disorders are caused by stress factors, dysbacteriosis or functional disorders, beneficial bacteria and neuropeptide support can help restore normal peristalsis and reduce pain, bloating, alternating constipation and diarrhea.

Recovery period after infections and taking antibiotics

Such probiotic-peptide complexes can accelerate the return of microflora to normal after a course of antibiotics or intestinal infections.
The presence of neuropeptides can support overall health, reduce fatigue and help regulate sleep.

Immune support

Up to 70% of immune cells are located in the intestinal mucosa. A balanced microbiome and additional peptide influence can strengthen the body's overall resistance to viruses and bacteria.
Such remedies are sometimes used as part of the prevention of seasonal infections (flu, acute respiratory viral infections), but this is only an addition, not the main preventive measure.

Stress and chronic fatigue

The mechanism of action here is similar: the correct balance of bacteria (especially L. helveticus, B. longum) in combination with neuropeptides can normalize the state of the nervous system, improve sleep, and reduce the severity of anxiety-depressive symptoms.

Application:

Recommendations for use: Can be used as a dietary supplement for the prevention and complex treatment of allergies, maintaining the physiological balance of normal microflora and having an antagonistic effect on pathogenic microorganisms. Suitable for children from 3 years old and adults. Before use, it is recommended to consult a doctor.

Directions for use:

Children from 3 to 12 years old - 1 capsule once a day.
Children over 12 years of age and adults - 1 capsule three times a day.
Take 30 minutes before meals.
The course duration is 1-2 months depending on the situation.

Contraindications: pregnancy, children under 3 years of age, hypersensitivity to components.

Storage conditions: store in the manufacturer's packaging, avoid humid conditions and proximity to heating devices to maintain the viability of lactic acid bacteria.

Compound:

1 capsule contains:

Not less than 1,000,000,000 CFU of live lyophilized bacteria immobilized on cellulose:
- Bifidobacterium bifidum, B. adolescentis, B. longum
- Lactobacillus acidophilus,
- L. delbrueckii subsp. bulgaricus,
- L. plantarum,
- L. fermentum,
- L. rhamnosus,
- L. reuteri
- Streptococcus salivarius
- Bacillus coagulans, Bacillus megaterium
Excipients: silicon dioxide, magnesium stearate.

Release form: capsules of 0.5 g ± 9%.

Bacterial strains: research and scientific basis

Lactobacillus rhamnosus (including strain GG)

Main research :
- Szajewska H. et al. (2013) showed that the strain L. rhamnosus GG is effective in the treatment and prevention of diarrheal conditions in children.
- Messaoudi M. et al. (2011) and other studies indicate that L. rhamnosus may influence behavior and anxiety levels through the gut-brain axis.
Potential benefits : normalizes bowel movements, reduces anxiety, supports the immune response.

Lactobacillus helveticus

Main research :
- Messaoudi M. et al. (2011): The combination of L. helveticus and Bifidobacterium longum reduced cortisol levels in adult volunteers, indicating a reduction in stress.
Potential benefits : emotional regulation, support for the gastrointestinal tract, help with some forms of irritable bowel syndrome (IBS).

Bifidobacterium longum / Bifidobacterium bifidum

Main research :
- Allen SJ et al. (2010) and El-aziz AM et al. (2021) describe the ability of bifidobacteria to alleviate IBS symptoms, improve peristalsis and reduce inflammation in the colon.
- When taking Lactobacillus + Bifidobacterium together, a synergistic effect is sometimes recorded: a reduction in abdominal pain and bloating.
Potential benefits : stabilization of microflora, strengthening of the intestinal barrier function, beneficial effect on the immune and psycho-emotional status.

*All results are individual and depend on your health condition.